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interference reflection microscopy
Interference reflection microscopy or IRM is an optical microscopy technique that utilizes polarized light to form an image of an object on a glass surface. The intensity of the signal is a measure of proximity of the object to the glass surface. This technique can be used to study events at the cell membrane without the use of a (fluorescent) label in contrast to TIRF microscopy.
==History==
The method was first used for the studying of thin films of oil. In 1964, the first application of the technique in cell biology was introduced by Curtis to study embryonic chick heart fibroblasts. He used IRM to look at adhesion sites and distances of fibroblasts, noting that contact with the glass was mostly limited to the cell periphery and the pseudopodia.〔
The technique was refined and the qualitative and quantitative aspects of the technique were later described by several researchers in the 70s and 80s: Bereiter-Hahn and his colleagues correlated the technique with electron microscopy, showing that different mammalian cell lines adhere to the glass substrate in specific focal adhesion sites.
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